one liner medics

As medical professionals, we all know that Apoptosis is defined as a programmed cell death and “it is a well-organized process”. On daily basis there are thousands of genomic injuries and wear & tear of the cell going on in the human body. The cellular debris i.e. phospholipid, nuclear material, mitochondria, ribosomes, centromere, etc. doesn’t spill out directly into the circulation, rather it is handed over to macrophages for Phagocytosis. When there is abnormal apoptosis, due to any genetic defect, the cellular debris spilled out into the main circulation, and our immune cells take them as antigens and start making antibodies against them. Which starts a widespread immune response against self-antigen, we call this condition auto Immune.  A wide range of auto-antibodies starts developing against self-antigen or (circulating remnants of a dead cell). These antigen-antibody complexes aka (immune complexes) start depositing in various tissues of our body. When these immune comp...

Image Source - Google | Image by -  https://www.bhf.org.uk/ Overview Amyloidosis is defined as a group of diseases, in which deposits of an abnormal protein called amyloid, form in tissues and organs throughout the body. Proteins are important molecules involved in almost each and every structure and function within our cells. They are made up of chains of smaller units called amino acids, which fold themselves into three-dimensional structures. This folding allows the protein to work properly and interact with other molecules. In amyloidosis, the proteins are made in the normal way, but when they are released from the cell they open up again. These abnormally folded proteins collect together in long chains or fibril, and the deposits they form are called amyloid. Historical Aspect Of The Disease “Amylin” a Latin word means “starch”. Matthias Schneider, a German Botanist was the first to use the term “amyloid” in botany, for starch, referring to “starch-like”. German pathologist Ru...